Preconditioning Local Injection of Activated Platelet-Rich Plasma Increases Angiogenesis, VEGF Levels, and Viability of Modified McFarlane Flap in Diabetes-Induced Rats

Preconditioning Local Injection of Activated Platelet-Rich Plasma Increases Angiogenesis, VEGF Levels, and Viability of Modified McFarlane Flap in Diabetes-Induced Rats

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Background The risk of flap necrosis in tissue reconstruction surgery is elevated in patients with vascular disorders, such as Conditioner Bar diabetes mellitus.Chronic hyperglycemia causes endothelial cell dysfunction and increases inflammatory Bike Accessories - Bags process, causing vascular insufficiency.Platelet-rich plasma (PRP) contains high levels of platelets, growth factors, and fibrinogens.Its regenerative properties spark interest in supporting flap survival in relation to diabetic complications.